Table 1 Summary of the clinical trials on vitamin D supplementation in patients with endometriosis
From: Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis
Author, year | Study design | Region | Participants, n | Age, year | Intervention (form) | Duration | Outcomes | Reference | |
|---|---|---|---|---|---|---|---|---|---|
pelvic pain | dysmenorrhea | ||||||||
Almassinokiani et al., 2016 | randomized, double-blind, placebo-controlled trial | Iran | Intervention: 19 Placebo: 20 | Intervention: 30.84 ± 5.79 Placebo: 28.95 ± 4.71 | vitamin D (50 000 IU weekly) | 12 weeks | P-value = 0.24* | p = 0.45* | [155] |
Nodler et al., 2020 | randomized, double-blind, placebo-controlled trial | USA | Intervention: 27 Placebo: 22 | Intervention: 20.0 ± 2.7 Placebo: 20.1 ± 3.5 | vitamin D (2000 IU daily) | 6 months | P-value = 0.91* |  | [156] |
Mehdizadehkashi et al., 2021 | randomized, double-blind, placebo-controlled trial | Iran | Intervention: 25 Placebo: 25 | Intervention: 35.6 ± 7.0 Placebo: 34.8 ± 7.1 | vitamin D (50 000 IU each 2 weeks) | 12 weeks | P-value = 0.03* |  | [157] |