Variable | COVID-19 period (n = 1821) | Historical cohort (n = 1944) | Total (N = 3765) | p-value* |
---|---|---|---|---|
 | n (%) | n (%) | N (%) |  |
Age (years) | Â | Â | Â | 0.001 |
 ≤ 19 | 26 (1.43) | 62 (3.19) | 88 (2.34) |  |
 > 19–24 | 186 (10.21) | 217 (11.16) | 403 (10.7) |  |
 > 24–35 | 1110 (60.96) | 1195 (61.47) | 2305 (61.22) |  |
 > 35–45 | 496 (27.24) | 468 (24.07) | 964 (25.6) |  |
 > 45 | 3 (0.16) | 2 (0.1) | 5 (0.13) |  |
Ethnicity | Â | Â | Â | 0.160 |
 Thai | 1756 (96.43) | 1891 (97.27) | 3647 (96.87) |  |
 Othersa | 65 (3.57) | 53 (2.73) | 118 (3.13) |  |
Marital status | Â | Â | Â | 0.255 |
 Single | 499 (27.4) | 496 (25.51) | 995 (26.43) |  |
 Married | 1258 (69.08) | 1368 (70.37) | 2626 (69.75) |  |
 Divorce | 1 (0.05) | 5 (0.26) | 6 (0.16) |  |
 Widow | 0 | 1 (0.05) | 1 (0.03) |  |
 No data of marital status | 63 (3.46) | 74 (3.81) | 137 (3.64) |  |
Residence | Â | Â | Â | 0.232 |
 Bangkok | 1164 (63.92) | 1279 (65.79) | 2443 (64.89) |  |
 Others | 657 (36.08) | 665 (34.21) | 1322 (35.11) |  |
Reimbursement | Â | Â | Â | 0.001 |
 Universal coverage | 311 (17.08) | 397 (20.42) | 708 (18.8) |  |
 Social security scheme | 1171 (64.31) | 1264 (65.02) | 2435 (64.67) |  |
 Self-paid | 103 (5.66) | 92 (4.73) | 195 (5.18) |  |
 KCMHb | 74 (4.06) | 47 (2.42) | 121 (3.21) |  |
 Government | 160 (8.79) | 144 (7.41) | 304 (8.07) |  |
 No data of reimbursement | 2 (0.11) | 0 | 2 (0.05) |  |
Gravidity | Â | Â | Â | 0.936 |
 1 | 908 (46.71) | 850 (46.68) | 908 (46.71) |  |
 2 | 647 (33.28) | 620 (34.05) | 647 (33.28) |  |
 3 | 265 (13.63) | 246 (13.51) | 265 (13.63) |  |
 4 | 94 (4.84) | 78 (4.28) | 94 (4.84) |  |
 ≥ 5 | 30 (1.54) | 27 (1.48) | 30 (1.54) |  |
Living child c | Â | Â | Â | 0.163 |
 0 | 1054 (57.88) | 1181 (60.75) | 2235 (59.36) |  |
 1 | 596 (32.73) | 593 (30.5) | 1189 (31.58) |  |
 2 | 142 (7.8) | 131 (6.74) | 273 (7.25) |  |
 ≥ 3 | 29 (1.59) | 39 (2.01) | 68 (1.81) |  |
Number of ANC | Â | Â | Â | 0.468 |
 0 | 10 (0.55) | 9 (0.46) | 19 (0.5) |  |
 1–4 | 64 (3.51) | 83 (4.27) | 147 (3.9) |  |
 ≥ 5 | 1747 (95.94) | 1852 (95.27) | 3599 (95.59) |  |
Pre-Pregnancy body mass index (kg/m 2 ) [20] | Â | Â | Â | 0.713 |
 Underweight < 18.5 | 287 (15.76) | 316 (16.26) | 603 (16.02) |  |
 Normal 18.5-<23 | 853 (46.84) | 935 (48.1) | 1788 (47.49) |  |
 Overweight 23-27.5 | 465 (25.54) | 479 (24.64) | 944 (25.07) |  |
 Obesity > 27.5 | 216 (11.86) | 213 (10.96) | 429 (11.39) |  |
 No data of pre-pregnancy BMI | 0 | 1 (0.05) | 1 (0.03) |  |
Underlying medical disease | ||||
 Yes | 198 (10.87) | 221 (11.37) | 419 (11.13) |  |
 No | 1623 (89.13) | 1723 (88.63) | 3346 (88.87) |  |
Hematologic disease d | Â | Â | Â | 0.061 |
 Yes | 93 (5.11) | 128 (6.58) | 221 (5.87) |  |
 No | 1728 (94.89) | 1816 (93.42) | 3544 (94.13) |  |
Endocrine disease e | Â | Â | Â | 0.745 |
 Yes | 44 (2.42) | 43 (2.21) | 87 (2.31) |  |
 No | 1777 (97.58) | 1901 (97.79) | 3678 (97.69) |  |
Psychiatric disease f | Â | Â | Â | 0.043 |
 Yes | 12 (0.66) | 4 (0.21) | 16 (0.42) |  |
 No | 1809 (99.34) | 1940 (99.79) | 3749 (99.58) |  |
Neurologic disease g |  |  |  | > 0.999 |
 Yes | 8 (0.44) | 9 (0.46) | 17 (0.45) |  |
 No | 1813 (99.56) | 1935 (99.54) | 3748 (99.55) |  |
Rheumatologic disease h | Â | Â | Â | 0.296 |
 Yes | 14 (0.77) | 9 (0.46) | 23 (0.61) |  |
 No | 1807 (99.23) | 1935 (99.54) | 3742 (99.39) |  |
Cancer i | Â | Â | Â | 0.442 |
 Yes | 9 (0.49) | 6 (0.31) | 15 (0.40) |  |
 No | 1812 (99.51) | 1938 (99.69) | 3750 (99.60) |  |
HIV status | Â | Â | Â | 0.312 |
 Positive | 9 (0.49) | 15 (0.77) | 24 (0.64) |  |
 Negative | 1812 (99.51) | 1929 (99.23) | 3741 (99.36) |  |
Hypertensive disorder | Â | Â | Â | 0.624 |
 No hypertensive disorder | 1651 (90.66) | 1784 (91.77) | 3435 (91.24) |  |
 Chronic hypertension | 21 (1.15) | 16 (0.82) | 37 (0.98) |  |
 Gestational hypertension | 47 (2.58) | 39 (2.01) | 86 (2.28) |  |
 Preeclampsia or eclampsia | 89 (4.89) | 92 (4.73) | 181 (4.81) |  |
 Chronic hypertension with superimpose preeclampsia | 13 (0.71) | 13 (0.67) | 26 (0.69) |  |
Diabetes | Â | Â | Â | 0.130 |
 No gestational diabetes | 1649 (90.55) | 1733 (89.15) | 3382 (89.83) |  |
 Gestational diabetes type 1 | 86 (4.72) | 89 (4.58) | 175 (4.65) |  |
 Gestational diabetes type 2 | 70 (3.84) | 91 (4.68) | 161 (4.28) |  |
 Overt DM | 16 (0.88) | 31 (1.59) | 47 (1.25) |  |
Placenta previa/low lying | Â | Â | Â | 0.304 |
 Yes | 33 (1.81) | 45 (2.31) | 78 (2.07) |  |
 No | 1788 (98.19) | 1899 (97.69) | 3687 (97.93) |  |
Previous cesarean section | Â | Â | Â | 0.286 |
 Yes | 336 (18.45) | 332 (17.08) | 668 (17.74) |  |
 No | 1485 (81.55) | 1612 (82.92) | 3097 (82.26) |  |
Previous myomectomy | Â | Â | Â | 0.714 |
 Yes | 13 (0.71) | 16 (0.82) | 29 (0.77) |  |
 No | 1808 (99.29) | 1928 (99.18) | 3736 (99.23) |  |
Multiple pregnancy | Â | Â | Â | 0.300 |
 Yes | 86 (4.72) | 78 (4.01) | 164 (4.36) |  |
 No | 1735 (95.28) | 1866 (95.99) | 3601 (95.64) |  |
Fetal complication j | Â | Â | Â | 0.048 |
 Yes | 61 (3.35) | 44 (2.26) | 105 (2.79) |  |
 No | 1760 (96.65) | 1900 (97.74) | 3660 (97.21) |  |
Oligohydramnios or polyhydramnios | Â | Â | Â | 0.241 |
 Yes | 34 (1.87) | 26 (1.34) | 60 (1.59) |  |
 No | 1787 (98.13) | 1918 (98.66) | 3705 (98.41) |  |
Primary infertility | Â | Â | Â | 0.195 |
 Yes | 85 (4.67) | 74 (3.81) | 159 (4.22) |  |
 No | 1736 (95.33) | 1870 (96.19) | 3606 (95.78) |  |
Route of delivery | Â | Â | Â | 0.192 |
 Vaginal delivery | 850 (46.68) | 949 (48.82) | 1799 (47.78) |  |
 Cesarean section | 971 (53.32) | 995 (51.18) | 1966 (52.22) |  |
Gestational age at delivery | Â | Â | Â | 0.818 |
 22–28 | 27 (1.48) | 29 (1.49) | 56 (1.49) |  |
 > 28–34 | 94 (5.16) | 96 (4.94) | 190 (5.05) |  |
 > 34–37 | 446 (24.49) | 453 (23.3) | 899 (23.88) |  |
 > 37 | 1254 (68.86) | 1366 (70.27) | 2620 (69.59) |  |
Birthweight (grams) | Â | Â | Â | 0.693 |
 Very low birthweight (< 1500) | 60 (3.29) | 66 (3.4) | 126 (3.35) |  |
 Low birth weight (1500–2500) | 223 (12.25) | 215 (11.06) | 438 (11.63) |  |
 Normal birth weight (2500–4000) | 1514 (83.14) | 1634 (84.05) | 3148 (83.61) |  |
 Large for gestational age (> 4000) | 24 (1.32) | 29 (1.49) | 53 (1.41) |  |
APGAR score at 1Â min | Â | Â | Â | 0.101 |
 0–3 | 19 (1.04) | 31 (1.59) | 50 (1.33) |  |
 4–6 | 51 (2.8) | 45 (2.31) | 96 (2.55) |  |
 7–10 | 1748 (95.99) | 1868 (96.09) | 3616 (96.04) |  |
 No data of APGAR score at 1 minutek | 3 (0.16) | 0 | 3 (0.08) |  |