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Table 2 Criteria for diagnosing pulmonary hypertension in bronchopulmonary dysplasia per the Pediatric Pulmonary Hypertension Network guidelines

From: Double-blind, non-inferiority, randomized controlled trial of dexamethasone 4, 5 and 6 mg for preventing adverse neonatal and maternal outcomes in very preterm to late preterm pregnancies between 29 0 and 36 6 weeks of gestation: study protocol

Level of severity

Echocardiography findings

No PHT

RVSP < 1/3 SBP by TR gradient; septal position rounded at end-systole of LV; no RVH; normal RV size and function; if present, large VSD or PDA gradients suggesting < 1/3 systemic RV pressures

Mild PHT

RVSP 1/3–1/2 SBP; flattening of IVS at end-systole of LV; mild RVH and RV dilatation; RV function may be normal

Moderate PHT

RVSP ½–2/3 SBP; flattening of IVS at end-systole of LV or with late systolic posterior bowing; moderate RVH or dilatation; RV may have reduced function

Severe PHT

RVSP > 2/3 SBP; if present, shunt with predominant R-L gradient; pansystolic posterior septal bowing; severe RVH; RV dilatation; low velocity shunting across PDA or VSD

  1. IVS interventricular septum, LV left ventricle, PDA patent ductus arteriosus, PHT pulmonary hypertension, R-L right to left, RV right ventricle, RVH right ventricular hypertrophy, RVSP right ventricular systolic pressure, SBP systolic blood pressure, TR tricuspid regurgitation, VSD ventricular septal defect