Table 2 The number of DALY cases and ASDR (per 100,000 individuals) of infertility in 2021, and percentage change of ASDR were analyzed across the GBD regions

Global

317,614 (116,288–752,758)

7.84 (2.85–18.56)

0.51% (0.38–0.65)

601,134 (213,158–1,468,475)

15.12 (5.35–36.88)

0.71% (0.54–0.88)

Andean Latin America

1308 (457–3074)

3.69 (1.29–8.74)

2.06% (1.72–2.4)

970 (83–3433)

2.71 (0.23–9.58)

8.11% (6.62–9.62)

Australasia

566 (208–1403)

3.76 (1.37–9.32)

0.26% (0.22–0.3)

135 (22–593)

0.87 (0.14–3.67)

0.83% (0.69–0.97)

Caribbean

1865 (701–4268)

7.74 (2.89–17.77)

– 0.12% (– 0.21–0.03)

3230 (1194–8225)

13.19 (4.88–33.64)

– 0.13% (– 0.28–0.03)

Central Asia

2798 (1071–6651)

5.44 (2.08–12.78)

0.34% (0.21–0.48)

4353 (1393–10,832)

8.44 (2.67–20.74)

0.83% (0.59–1.07)

Central Europe

4209 (1490–10604)

7.77 (2.74–19.83)

0.58% (0.48–0.68)

7124 (2268–18,324)

13.6 (4.29–34.98)

0.84% (0.71–0.98)

Central Latin America

7737 (2830–17728)

5.93 (2.18–13.66)

0.49% (0.26–0.72)

12,076 (3458–32,018)

8.71 (2.5–23.2)

1.17% (0.79–1.55)

Central Sub-Saharan Africa

4740 (1668–11,334)

7.86 (2.75–19.15)

– 0.35% (– 0.75–0.05)

9141 (2975–21,605)

15.23 (4.7–35.74)

– 0.13% (– 0.73–0.47)

East Asia

65,671 (22,295–160,100)

8.57 (2.94–20.87)

0.02% (– 0.04–0.09)

157,326 (51,989–406,568)

21.55 (7.4–54.1)

0.02% (– 0.03–0.07)

Eastern Europe

11,889 (4220–29847)

12.2 (4.27–30.22)

0.26% (0.16–0.37)

20,006 (6812–52,654)

20.11 (7.05–51.09)

0.58% (0.45–0.7)

Eastern Sub-Saharan Africa

8420 (3013–19823)

4.37 (1.59–10.17)

– 1.17% (– 1.39–0.95)

21,486 (7752–50,131)

10.57 (3.79–25.04)

– 1.23% (– 1.49–0.97)

High-income Asia Pacific

4516 (1588–11,264)

5.17 (1.8–12.84)

– 0.19% (– 0.27–0.11)

2963 (191–11,210)

3.24 (0.24–12.55)

– 0.4% (– 0.65–0.15)

High-income North America

10,826 (3847–26,993)

6.26 (2.19–15.78)

0.76% (0.12–1.41)

8507 (1021–26836)

4.9 (0.58–15.3)

2.91% (1.51–4.33)

High-middle SDI

57,219 (21,039–141093)

8.35 (3.02–20.74)

0.14% (0.13–0.16)

112,846 (38,219–282,874)

17.04 (5.87–41.71)

0.27% (0.24–0.29)

High SDI

34,878 (12,752–84,167)

6.4 (2.3–15.53)

0.6% (0.48–0.72)

41,101 (11,612–110,625)

7.83 (2.2–21.41)

1.41% (1.25–1.56)

Low-middle SDI

84,065 (30,521–196576)

8.18 (2.98–19.2)

0.95% (0.57–1.33)

167,400 (58,563–403,460)

16.34 (5.7–39.57)

1.19% (0.65–1.73)

Low SDI

37,248 (13,729–85,517)

7.28 (2.7–16.88)

– 0.16% (– 0.44–0.12)

67,696 (24,767–161,485)

12.8 (4.73–31.1)

0.11% (– 0.28–0.5)

Middle SDI

103,980 (38,249–249,703)

7.98 (2.9–19.24)

0.66% (0.58–0.75)

211,708 (75,088–517044)

16.47 (5.84–39.99)

0.62% (0.5–0.74)

North Africa and Middle East

25,132 (9234–57,501)

7.02 (2.56–16.24)

0.73% (0.55–0.91)

35,930 (11,008–89848)

10.93 (3.36–27.16)

1.09% (0.78–1.4)

Oceania

292 (110–676)

4.08 (1.55–9.43)

– 0.94% (– 1.13–0.74)

416 (144–1001)

5.9 (2.05–14.25)

– 1.53% (– 1.8–1.26)

South Asia

90,312 (32,227–209,136)

8.67 (3.11–20.15)

1.43% (0.89–1.96)

199,476 (71,920–470290)

19.74 (7.09–46.79)

1.85% (1.13–2.57)

Southeast Asia

31,369 (11,255–73,878)

8.19 (2.93–19.24)

1.55% (1.28–1.82)

60,681 (21,015–150690)

16.11 (5.57–40.33)

1.66% (1.33–1.98)

Southern Latin America

2142 (776–5318)

6.02 (2.19–14.98)

– 0.04% (– 0.1–0.03)

2160 (370–6141)

5.93 (1.01–17.1)

– 0.26% (– 0.34–0.18)

Southern Sub-Saharan Africa

1819 (619–4609)

4.08 (1.39–10.21)

– 0.72% (– 1.26–0.18)

4197 (1096–11247)

9.21 (2.42–24.57)

– 0.8% (– 1.54–0.06)

Tropical Latin America

8117 (2920–19585)

6.53 (2.37–15.72)

1.76% (1.34–2.18)

12,166 (3807–32977)

9.35 (3–25.33)

1.62% (1.05–2.21)

Western Europe

11,857 (4236–29,090)

6.03 (2.13–14.95)

0.93% (0.74–1.12)

14,102 (3264–39,770)

6.99 (1.63–19.39)

1.44% (1.17–1.72)

Western Sub-Saharan Africa

22,028 (8143–51,657)

10.78 (3.94–25.15)

– 0.6% (– 0.87–0.34)

24,687 (7276–61,455)

10.97 (3.17–27.28)

– 0.3% (– 0.57–0.03)