Clinical criteria | Acute onset of fever > 38.5 °C and severe arthralgia/arthritis not explained by other medical conditions |
Epidemiological criteria | Residing or having visited epidemic areas having reported transmission within 15Â days prior to the onset of symptoms |
Laboratory criteria | Virus isolation Presence of viral RNA by RT-PCR Presence of virus-specific IgM antibodies in single serum sample collected in acute or convalescent stage Four-fold increase in IgG values in samples collected at least 3Â weeks apart |
Suspect case | Any person with acute onset of fever > 38.5 °C and severe arthralgia/arthritis not explained by other medical conditions |
Probable case | A patient meeting both the clinical and epidemiological criteria |
Confirmed case | A suspected case with laboratory confirmation |